Hampton Inn Florence-Midtown is a well-maintained hotel that guests often choose for its cleanliness, friendly staff, and good location. The rooms are generally clean, with some reviews highlighting functioning features, attractive decor, and amenities like walk-in showers. Many visitors appreciate the cleanliness of the facilities and grounds, along with the friendly, caring staff who go out of their way to ensure a comfortable stay. The hotel offers amenities such as a gym, an outside pool, and a decent complimentary breakfast that guests find tasty and hot. Its location is convenient for attending local events and exploring nearby places, making it the preferred choice for repeat visitors. However, some reviews mention issues like dirty hall carpets, strong room deodorizers, and maintenance problems such as low water pressure and a falling AC cover. A serious concern was raised when a guest's purse was taken from the room without their knowledge during cleaning, leading to frustration and lack of response from management. Overall, Hampton Inn Florence-Midtown is regarded as a friendly, clean, and comfortable hotel, with staff that are attentive and considerate, though a few incidents have marred some guests’ experiences.