Palmetto Goodwill offers a diverse selection of clothing and household items, though the organization and cleanliness of the store can be inconsistent. Customers report finding quality brand-name items, such as Abercrombie, Ralph Lauren, and Brooks Brothers, at affordable prices. However, the selection is described as "mediocre" at times, with some donated goods appearing worn or non-functional. The store's layout can be disorganized, with tangled displays and jumbled shelves. Despite these challenges, the staff is consistently praised for their friendliness and helpfulness. Overall, Palmetto Goodwill provides a mixed shopping experience, with the potential for great bargains balanced by the store's variable condition and organization.