CVS in Port Saint Lucie is open seven days a week, offering prescription refills, COVID-19 or flu tests, vaccinations, personal care items, and more. The store is always clean and organized with plenty of parking. Customers report excellent customer service, with staff described as kind, friendly, knowledgeable, and helpful, often going above and beyond. The efficient service makes for a productive and enjoyable visit. Shoppers can find good deals periodically, save with ExtraCare rewards, and use options like self-checkout, free pickup, or same-day delivery. It is consistently noted as a great place to visit for reliable value and helpful service.